A US regulator have opened an investigation into the relationships between leading artificial intelligence start-ups such as ChatGPT maker OpenAI and the tech giants that have invested billions of dollars in them.

“We’re scrutinising whether these ties enable dominant firms to exert undue influence or gain privileged access in ways that could undermine fair competition,” said Lina Khan, chairwoman of the US Federal Trade Commission, in opening remarks at an AI forum.

The FTC said it has issued “compulsory orders” to five companies requiring them to provide information regarding investments and partnerships.

All of the leading cloud providers — Amazon, Google and Microsoft — have made huge investments in AI firms, most notably Microsoft’s close partnership with OpenAI.

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Lina Khan leads the Federal Trade Commission (Saul Loeb/Pool Photo via AP)

Both Google and Amazon have made multibillion-dollar deals with Anthropic, another San Francisco-based AI start-up created by former leaders at OpenAI.

The European Union and the United Kingdom have already signalled that they might scrutinise the relationship with Microsoft and OpenAI.

The EU’s executive branch said in January it was checking whether the partnership might trigger an investigation under regulations covering mergers and acquisitions that would harm competition in the 27-nation bloc.

The review could lead to a formal investigation into whether the deal should be unconditionally cleared, allowed with concessions from the companies or blocked.

Microsoft has never publicly disclosed the total dollar amount of its investment in OpenAI, which CEO Satya Nadella has described as a “complicated thing”.

“We have a significant investment,” he said on a November podcast hosted by tech journalist Kara Swisher. “It sort of comes in the form of not just dollars but it comes in the form of compute and what have you.”

Microsoft made its first 1 billion dollar investment in San Francisco-based OpenAI in 2019, more than two years before the start-up introduced ChatGPT and sparked worldwide fascination with AI advances.

As part of the deal, the Washington software giant would supply computing power — such as from one of its data centres in rural Iowa — needed to train the AI models on huge troves of human-written texts and other media.

In turn, Microsoft would get exclusive rights to much of what OpenAI built, enabling the technology to be infused into a variety of Microsoft products.

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Microsoft CEO Satya Nadella has defended links with OpenAI (Kin Cheung)

Mr Nadella in January compared it to a number of long-standing Microsoft commercial partnerships, such as with chipmaker Intel.

Microsoft and OpenAI “are two different companies, answerable to two sets of different stakeholders with different interests”, he told a Bloomberg reporter at the World Economic Forum in Davos, Switzerland.

“So we build the compute. They then use the compute to do the training. We then take that, put it into products. And so in some sense it’s a partnership that is based on each of us really reinforcing what… each other does and then ultimately being competitive in the marketplace.”

The FTC has signalled for nearly a year that it is working to track and stop illegal behaviour in the use and development of AI tools.

Ms Khan said in April that the US government would “not hesitate to crack down” on harmful business practices involving AI. One target of popular concern is the use of AI-generated voices and imagery to turbocharge fraud and phone scams.

But increasingly, Ms Khan also made clear that it is not just harmful applications but the broader consolidation of market power into a handful of AI leaders that deserves government scrutiny.

“Companies may use this market-tipping moment to leverage anti-competitive tactics to lock in their dominance and block competition,” the FTC said in a preview of Thursday’s forum.